| 报告题目： |
Developing multi-scale approach to reveal the mechanism of molecular motor’s motility |
| 报告人： |
Prof. Lin Li （李林） |
| 报告人单位： |
University of Texas at El Paso |
| 报告时间： |
5月27号（星期一）上午8:00 |
| 报告地点： |
科技楼北410 |
| 报告人简介： |
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Dr. Lin Li is an Assistant Professor in Physics at the University of Texas at El Paso. He received his BS from the Huazhong University of Science and Technology in 2005 and PhD from the Huazhong University of Science and Technology in 2011. His research interests include computational biophysics, computational biology, bioinformatics, protein interactions, virus capsid assembly, and molecular motor. He develops state of art software packages for modeling and simulations of biological systems, and uses computational approaches to study important biological systems. |
| 报告摘要： |
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Electrostatic interactions play important roles in Biology. Therefore, a lot of efforts have been made to model the electrostatic interactions in biological systems. However, it is extremely challenging to accurately calculate the electrostatic interactions in large biological systems such as dynein, a molecular motor important for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. I will introduce a novel multi-scale simulation approach which is used to study dynein’s motion along microtubules. The electrostatic binding funnel around microtubule is observed, which drags the dynein to the binding pocket. The electrostatic forces on dynein residues form a torsion which reorients the dynein when it is in an un-native orientation. Furthermore, the electrostatic component of the binding energy of dynein and microtubule strongly affects the velocity and run length of the dynein. These results reveal the mechanisms of dynein’s motility and functions along microtubule. Understanding such fundamental mechanisms sheds light on curing many molecular motor related diseases. |
